Anti-GP6 antibody (21-267) (STJ117197)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GP6 (21-267) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GP6 |
| Gene ID | 51206 |
| Uniprot ID | GPVI_HUMAN |
| Immunogen Region | 21-267 |
| Immunogen Sequence | QSGPLPKPSLQALPSSLVPL EKPVTLRCQGPPGVDLYRLE KLSSSRYQDQAVLFIPAMKR SLAGRYRCSYQNGSLWSLPS DQLELVATGVFAKPSLSAQP GPAVSSGGDVTLQCQTRYGF DQFALYKEGDPAPYKNPERW YRASFPIITVTAAHSGTYRC YSFSSRDPYLWSAPSDPLEL VVTGTSVTPSRLPTEPPSPV AEFSEATAELTVSFTNEVFT TETSRSITASPKESDSPAG |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 21-267 of human GP6 (NP_057447.5). |
Additional Info
| Tissue Specificity | Megakaryocytes and platelets. |
| Post Translational Modifications | N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX). |
| Function | Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. |
| Protein Name | Platelet Glycoprotein ViGpviGlycoprotein 6 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-202733Reactome: R-HSA-75892 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Membrane ProteinIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Platelet Glycoprotein Vi antibodyAnti-Gpvi antibodyAnti-Glycoprotein 6 antibodyAnti-GP6 antibody |
Information sourced from Uniprot.org