![Anti-GOT1 antibody (150-250) [S7MR] (STJ11101317)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/90230/359294/STJ11101317_1__54492.1713123727.jpg?c=1 "Anti-GOT1 antibody (150-250) [S7MR] (STJ11101317)")
![Anti-GOT1 antibody (150-250) [S7MR] (STJ11101317)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/90230/359294/STJ11101317_1__54492.1713123727.jpg?c=1 "Anti-GOT1 antibody (150-250) [S7MR] (STJ11101317)")
Anti-GOT1 antibody (150-250) [S7MR] (STJ11101317)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal GOT1 (150-250) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S7MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GOT1 |
| Gene ID | 2805 |
| Uniprot ID | AATC_HUMAN |
| Immunogen Region | 150-250 |
| Immunogen Sequence | AAGFKDIRSYRYWDAEKRGL DLQGFLNDLENAPEFSIVVL HACAHNPTGIDPTPEQWKQI ASVMKHRFLFPFFDSAYQGF ASGNLERDAWAIRYFVSEGF E |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human GOT1 (NP_002070.1). |
Additional Info
| Function | Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway. |
| Protein Name | Aspartate Aminotransferase - CytoplasmicCaspatCysteine Aminotransferase - CytoplasmicCysteine Transaminase - CytoplasmicCcatGlutamate Oxaloacetate Transaminase 1Transaminase A |
| Database Links | Reactome: R-HSA-1237112Reactome: R-HSA-8963693Reactome: R-HSA-9856872 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Aspartate Aminotransferase - Cytoplasmic antibodyAnti-Caspat antibodyAnti-Cysteine Aminotransferase - Cytoplasmic antibodyAnti-Cysteine Transaminase - Cytoplasmic antibodyAnti-Ccat antibodyAnti-Glutamate Oxaloacetate Transaminase 1 antibodyAnti-Transaminase A antibodyAnti-GOT1 antibody |
Information sourced from Uniprot.org