Anti-GOPC antibody (195-454) (STJ29649)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GOPC (195-454) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GOPC |
| Gene ID | 57120 |
| Uniprot ID | GOPC_HUMAN |
| Immunogen Region | 195-454 |
| Immunogen Sequence | ARLAAKYLDKELAGRVQQIQ LLGRDMKGPAHDKLWNQLEA EIHLHRHKTVIRACRGRNDL KRPMQAPPGHDQDSLKKSQG VGPIRKVLLLKEDHEGLGIS ITGGKEHGVPILISEIHPGQ PADRCGGLHVGDAILAVNGV NLRDTKHKEAVTILSQQRGE IEFEVVYVAPEVDSDDENVE YEDESGHRYRLYLDELEGGG NPGASCKDTSGEIKVLQGFN KKAVTDTHENGDLGTASET |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 195-454 of human PIST/PIST/GOPC (NP_001017408.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR. Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes. |
| Protein Name | Golgi-Associated Pdz And Coiled-Coil Motif-Containing ProteinCftr-Associated LigandFused In GlioblastomaPdz Protein Interacting Specifically With Tc10Pist |
| Database Links | Reactome: R-HSA-5627083Reactome: R-HSA-9013406 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneSynapsePostsynaptic DensityCell ProjectionDendriteEnriched In Synaptosomal And Postsynaptic Densities (Psd) FractionsExpressed In Cell Bodies And Dendrites Of Purkinje CellsLocalized At The Trans-Golgi Network (Tgn) Of Spermatids And The Medulla Of Round Spermatides |
| Alternative Antibody Names | Anti-Golgi-Associated Pdz And Coiled-Coil Motif-Containing Protein antibodyAnti-Cftr-Associated Ligand antibodyAnti-Fused In Glioblastoma antibodyAnti-Pdz Protein Interacting Specifically With Tc10 antibodyAnti-Pist antibodyAnti-GOPC antibodyAnti-CAL antibodyAnti-FIG antibody |
Information sourced from Uniprot.org