Anti-GNS antibody (293-552) (STJ29625)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GNS (293-552) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GNS |
| Gene ID | 2799 |
| Uniprot ID | GNS_HUMAN |
| Immunogen Region | 293-552 |
| Immunogen Sequence | WQTLLSVDDLVEKLVKRLEF TGELNNTYIFYTSDNGYHTG QFSLPIDKRQLYEFDIKVPL LVRGPGIKPNQTSKMLVANI DLGPTILDIAGYDLNKTQMD GMSLLPILRGASNLTWRSDV LVEYQGEGRNVTDPTCPSLS PGVSQCFPDCVCEDAYNNTY ACVRTMSALWNLQYCEFDDQ EVFVEVYNLTADPDQITNIA KTIDPELLGKMNYRLMMLQS CSGPTCRTPGVFDPGYRFD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 293-552 of human GNS (NP_002067.1). |
Additional Info
| Post Translational Modifications | The form A (78 kDa) is processed by internal peptidase cleavage to a 32 kDa N-terminal species (form B) and a 48 kDa C-terminal species. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
| Function | Hydrolyzes 6-sulfate groups in N-acetyl-d-glucosaminide units of heparin sulfate and keratan sulfate. |
| Protein Name | N-Acetylglucosamine-6-SulfataseGlucosamine-6-SulfataseG6s |
| Database Links | Reactome: R-HSA-2022857Reactome: R-HSA-2206305Reactome: R-HSA-432720Reactome: R-HSA-6798695 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-N-Acetylglucosamine-6-Sulfatase antibodyAnti-Glucosamine-6-Sulfatase antibodyAnti-G6s antibodyAnti-GNS antibody |
Information sourced from Uniprot.org