Anti-GNPDA2 antibody (STJA0007661)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human GNPDA2
General Information
| Short Description | Rabbit polyclonal anti-Glucosamine-6-phosphate isomerase 2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GNPDA2 |
| Gene ID | 132789 |
| Uniprot ID | GNPI2_HUMAN |
| Immunogen | Synthesized peptide derived from human GNPDA2 |
| Specificity | This antibody detects endogenous levels of GNPDA2 at Human, Mouse |
Additional Info
| Function | Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. |
| Protein Name | Glucosamine-6-Phosphate Deaminase 2Glcn6p Deaminase 2Glucosamine-6-Phosphate Isomerase 2Glucosamine-6-Phosphate Isomerase Sb52 |
| Database Links | Reactome: R-HSA-70171 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Glucosamine-6-Phosphate Deaminase 2 antibodyAnti-Glcn6p Deaminase 2 antibodyAnti-Glucosamine-6-Phosphate Isomerase 2 antibodyAnti-Glucosamine-6-Phosphate Isomerase Sb52 antibodyAnti-GNPDA2 antibodyAnti-GNP2 antibody |
Information sourced from Uniprot.org