Anti-GNPDA1 antibody (1-70) (STJ115671)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GNPDA1 (1-70) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GNPDA1 |
| Gene ID | 10007 |
| Uniprot ID | GNPI1_HUMAN |
| Immunogen Region | 1-70 |
| Immunogen Sequence | MKLIILEHYSQASEWAAKYI RNRIIQFNPGPEKYFTLGLP TGSTPLGCYKKLIEYYKNGD LSFKYVKTFN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human GNPDA1 (NP_005462.1). |
Additional Info
| Function | Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo. |
| Protein Name | Glucosamine-6-Phosphate Deaminase 1Glcn6p Deaminase 1Glucosamine-6-Phosphate Isomerase 1Protein Oscillin |
| Database Links | Reactome: R-HSA-70171 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Glucosamine-6-Phosphate Deaminase 1 antibodyAnti-Glcn6p Deaminase 1 antibodyAnti-Glucosamine-6-Phosphate Isomerase 1 antibodyAnti-Protein Oscillin antibodyAnti-GNPDA1 antibodyAnti-GNPI antibodyAnti-HLN antibodyAnti-KIAA0060 antibody |
Information sourced from Uniprot.org