Anti-GNL3 antibody (1-240) (STJ28542)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GNL3 (1-240) antibody for use in WB, IF, ICC, IP and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:10-1:100IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GNL3 |
| Gene ID | 26354 |
| Uniprot ID | GNL3_HUMAN |
| Immunogen Region | 1-240 |
| Immunogen Sequence | MTCHKRYKIQKKVREHHRKL RKEAKKRGHKKPRKDPGVPN SAPFKEALLREAELRKQRLE ELKQQQKLDRQKELEKKRKL ETNPDIKPSNVEPMEKEFGL CKTENKAKSGKQNSKKLYCQ ELKKVIEASDVVLEVLDARD PLGCRCPQVEEAIVQSGQKK LVLILNKSDLVPKENLESWL NYLKKELPTVVFRASTKPKD KGKITKRVKAKKNAAPFRSE VCFGKEGLWKLLGGFQETC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human GNL3 (NP_996562.1). |
Additional Info
| Tissue Specificity | Increased levels in lung tissue in cancer patients. |
| Function | May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. |
| Protein Name | Guanine Nucleotide-Binding Protein-Like 3E2-Induced Gene 3 ProteinNovel Nucleolar Protein 47Nnp47Nucleolar Gtp-Binding Protein 3Nucleostemin |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusShuttles Between The Nucleus And Nucleolus |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein-Like 3 antibodyAnti-E2-Induced Gene 3 Protein antibodyAnti-Novel Nucleolar Protein 47 antibodyAnti-Nnp47 antibodyAnti-Nucleolar Gtp-Binding Protein 3 antibodyAnti-Nucleostemin antibodyAnti-GNL3 antibodyAnti-E2IG3 antibodyAnti-NS antibody |
Information sourced from Uniprot.org