• Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-GNA13 antibody (STJ190857)

SKU:
STJ190857

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Guanine nucleotide-binding protein subunit alpha-13 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GNA13
Gene ID: 10672
Uniprot ID: GNA13_HUMAN
Specificity: GNA13 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Palmitoylation is critical for proper membrane localization and signaling. Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation.
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation.
Protein Name Guanine Nucleotide-Binding Protein Subunit Alpha-13
G Alpha-13
G-Protein Subunit Alpha-13
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-416482
Reactome: R-HSA-428930
Reactome: R-HSA-456926
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Cellular Localisation Cell Membrane
Lipid-Anchor
Melanosome
Cytoplasm
Nucleus
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Detected In The Cytoplasm Of Leydig Cells And In The Seminiferous Epithelium
Including Differentiating Cells From The Spermatogonia To Mature Spermatozoa Stages
In Round Spermatids
Also Present In The Nuclei
Alternative Antibody Names Anti-Guanine Nucleotide-Binding Protein Subunit Alpha-13 antibody
Anti-G Alpha-13 antibody
Anti-G-Protein Subunit Alpha-13 antibody
Anti-GNA13 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance