• STJ72384 (0. 3µg/ml) staining of Rat Kidney lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.

Anti-GM2A antibody (179-189) (STJ72384)

SKU:
STJ72384-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-GM2A (179-189) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.3-1µg/ml
ELISA-antibody detection limit dilution 1:4000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: GM2A
Gene ID: 2760
Uniprot ID: SAP3_HUMAN
Immunogen Region: 179-189
Accession Number: NP_000396.2
Specificity: This antibody is expected to recognize isoform 1 (NP_000396.2) only.
Immunogen Sequence: KRLGCIKIAAS
Function The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity.
Protein Name Ganglioside Gm2 Activator
Cerebroside Sulfate Activator Protein
Gm2-Ap
Sphingolipid Activator Protein 3
Sap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short
Database Links Reactome: R-HSA-1660662
Reactome: R-HSA-6798695
Cellular Localisation Lysosome
Alternative Antibody Names Anti-Ganglioside Gm2 Activator antibody
Anti-Cerebroside Sulfate Activator Protein antibody
Anti-Gm2-Ap antibody
Anti-Sphingolipid Activator Protein 3 antibody
Anti-Sap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short antibody
Anti-GM2A antibody

Information sourced from Uniprot.org

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