Anti-GLYAT/GAT antibody (1-100 aa) [SRM5425] (STJ11107338)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal GLYAT/GAT (1-100 aa) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5425 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GLYAT |
| Gene ID | 10249 |
| Uniprot ID | GLYAT_HUMAN |
| Immunogen Region | 1-100 aa |
| Immunogen Sequence | MMLPLQGAQMLQMLEKSLRK SLPASLKVYGTVFHINHGNP FNLKAVVDKWPDFNTVVVCP QEQDMTDDLDHYTNTYQIYS KDPQNCQEFLGSPELINWKQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human GLYAT/GAT (NP_964011.2). |
Additional Info
| Tissue Specificity | Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers. |
| Function | Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. |
| Protein Name | Glycine N-AcyltransferaseAcyl-Coa -Glycine N-AcyltransferaseAacAralkyl Acyl-Coa N-AcyltransferaseAralkyl Acyl-Coa -Amino Acid N-AcyltransferaseBenzoyl-Coenzyme A -Glycine N-AcyltransferaseGlycine N-BenzoyltransferaseHrp-1(Clp |
| Database Links | Reactome: R-HSA-177128Reactome: R-HSA-177135Reactome: R-HSA-9749641 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Glycine N-Acyltransferase antibodyAnti-Acyl-Coa -Glycine N-Acyltransferase antibodyAnti-Aac antibodyAnti-Aralkyl Acyl-Coa N-Acyltransferase antibodyAnti-Aralkyl Acyl-Coa -Amino Acid N-Acyltransferase antibodyAnti-Benzoyl-Coenzyme A -Glycine N-Acyltransferase antibodyAnti-Glycine N-Benzoyltransferase antibodyAnti-Hrp-1(Clp antibodyAnti-GLYAT antibodyAnti-ACGNAT antibodyAnti-CAT antibodyAnti-GAT antibody |
Information sourced from Uniprot.org