Anti-GLUT4/SLC2A4 antibody [SAA1533] (STJA0019961)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Solute Carrier Family 2-Facilitated Glucose Transporter Member 4 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1533 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | SLC2A4 |
| Gene ID | 6517 |
| Uniprot ID | GLUT4_HUMAN |
Additional Info
| Post Translational Modifications | Sumoylated. Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane. |
| Function | Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. |
| Protein Name | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 4Glucose Transporter Type 4 - Insulin-ResponsiveGlut-4 |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-189200Reactome: R-HSA-381340 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndomembrane SystemCytoplasmPerinuclear RegionLocalizes Primarily To The Perinuclear RegionUndergoing Continued Recycling To The Plasma Membrane Where It Is Rapidly ReinternalizedThe Dileucine Internalization Motif Is Critical For Intracellular SequestrationInsulin Stimulation Induces Translocation To The Cell Membrane |
| Alternative Antibody Names | Anti-Solute Carrier Family 2 - Facilitated Glucose Transporter Member 4 antibodyAnti-Glucose Transporter Type 4 - Insulin-Responsive antibodyAnti-Glut-4 antibodyAnti-SLC2A4 antibodyAnti-GLUT4 antibody |
Information sourced from Uniprot.org