Anti-GLS2 antibody (545-602) (STJ118469)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GLS2 (545-602) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GLS2 |
| Gene ID | 27165 |
| Uniprot ID | GLSL_HUMAN |
| Immunogen Region | 545-602 |
| Immunogen Sequence | NPFAKDRWGNIPLDDAVQFN HLEVVKLLQDYQDSYTLSET QAEAAAEALSKENLESMV |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 545-602 of human GLS2 (NP_037399.2). |
Additional Info
| Tissue Specificity | Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas. |
| Function | Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. |
| Protein Name | Glutaminase Liver Isoform - MitochondrialGlsL-GlutaminaseL-Glutamine Amidohydrolase |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-5628897Reactome: R-HSA-8964539 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Glutaminase Liver Isoform - Mitochondrial antibodyAnti-Gls antibodyAnti-L-Glutaminase antibodyAnti-L-Glutamine Amidohydrolase antibodyAnti-GLS2 antibodyAnti-GA antibody |
Information sourced from Uniprot.org