| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Glycine receptor subunit alpha-3 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GLRA3 |
| Gene ID: |
8001 |
| Uniprot ID: |
GLRA3_HUMAN |
| Specificity: |
This antibody detects endogenous levels of GLRA3 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human GLRA3 |
| Post Translational Modifications | Phosphorylated by PKA.this causes down-regulation of channel activity. |
| Function | Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition.heteropentameric channels display faster channel closure. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Contributes to increased pain perception in response to increased prostaglandin E2 levels. Plays a role in cellular responses to ethanol. |
| Protein Name | Glycine Receptor Subunit Alpha-3 |
| Database Links | Reactome: R-HSA-112314 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinPerikaryonCell ProjectionDendriteSynapseCell MembranePartially Colocalizes With Gphn That Is Known To Mediate Receptor Clustering At Postsynaptic Membranes |
| Alternative Antibody Names | Anti-Glycine Receptor Subunit Alpha-3 antibodyAnti-GLRA3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
