Anti-GLRA3 antibody (STJA0007641)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human GLRA3
General Information
| Short Description | Rabbit polyclonal anti-Glycine receptor subunit alpha-3 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GLRA3 |
| Gene ID | 8001 |
| Uniprot ID | GLRA3_HUMAN |
| Immunogen | Synthesized peptide derived from human GLRA3 |
| Specificity | This antibody detects endogenous levels of GLRA3 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated by PKA.this causes down-regulation of channel activity. |
| Function | Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition.heteropentameric channels display faster channel closure. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Contributes to increased pain perception in response to increased prostaglandin E2 levels. Plays a role in cellular responses to ethanol. |
| Protein Name | Glycine Receptor Subunit Alpha-3 |
| Database Links | Reactome: R-HSA-112314 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinPerikaryonCell ProjectionDendriteSynapseCell MembranePartially Colocalizes With Gphn That Is Known To Mediate Receptor Clustering At Postsynaptic Membranes |
| Alternative Antibody Names | Anti-Glycine Receptor Subunit Alpha-3 antibodyAnti-GLRA3 antibody |
Information sourced from Uniprot.org