Anti-Glial cell-derived neurotrophic factor receptor alpha-2 antibody (aa: 376-390) (STJA0040835)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeMixed
ImmunogenA synthetic peptide (PRVEKTPSLPDDLSD) as a part of human GFR alpha-2 protein (aa: 376-390) conjugated to KLH.
General Information
| Short Description | Rabbit polyclonal anti-Glial cell-derived neurotrophic factor receptor alpha-2 (aa: 376-390) for use in IHC-F and WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F/WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | Mixed |
| Conjugation | Unconjugated |
| Purification | Whole serum |
| Dilution Range | WB 1:500-1:1000IHC 1:500-1:1000 |
| Storage Instruction | Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at-20°C for a higher stability, and at 2-8°C with an appropriate antibacterial |
Target Information
| Gene Symbol | GFRA2 |
| Gene ID | 2675 |
| Uniprot ID | GFRA2_HUMAN |
| Immunogen | A synthetic peptide (PRVEKTPSLPDDLSD) as a part of human GFR alpha-2 protein (aa: 376-390) conjugated to KLH. |
| Immunogen Region | aa: 376-390 |
| Immunogen Sequence | Human |
| Specificity | Western blot analysis indicates a high level of specificity to GFR alpha-2 for this antiserum. This antibody is known to react with rat GFR alpha-2 and from IHC analysis, there appears to be no cross-reactivity with other members of the GFR family. |
Additional Info
| Tissue Specificity | Isoform 1: found in both brain and placenta. |
| Function | Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3. |
| Protein Name | Gdnf Family Receptor Alpha-2Gdnf Receptor Alpha-2Gdnfr-Alpha-2Gfr-Alpha-2Gdnf Receptor BetaGdnfr-BetaNeurturin Receptor AlphaNrtnr-AlphaNtnr-AlphaRet Ligand 2Tgf-Beta-Related Neurotrophic Factor Receptor 2 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-2 antibodyAnti-Gdnf Receptor Alpha-2 antibodyAnti-Gdnfr-Alpha-2 antibodyAnti-Gfr-Alpha-2 antibodyAnti-Gdnf Receptor Beta antibodyAnti-Gdnfr-Beta antibodyAnti-Neurturin Receptor Alpha antibodyAnti-Nrtnr-Alpha antibodyAnti-Ntnr-Alpha antibodyAnti-Ret Ligand 2 antibodyAnti-Tgf-Beta-Related Neurotrophic Factor Receptor 2 antibodyAnti-GFRA2 antibodyAnti-GDNFRB antibodyAnti-RETL2 antibodyAnti-TRNR2 antibody |
Information sourced from Uniprot.org