| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GIGYF2 (350-500) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GIGYF2 |
| Gene ID: |
26058 |
| Uniprot ID: |
GGYF2_HUMAN |
| Immunogen Region: |
350-500 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 350-500 of human GIGYF2 (NP_001096617.1). |
| Immunogen Sequence: |
VDEGEECSDSEGSHNEEAKE PDKTNKKEGEKTDRVGVASE ETPQTSSSSARPGTPSDHQS QEASQFERKDEPKTEQTEKA EEETRMENSLPAKVPSRGDE MVADVQQPLSQIPSDTASPL LILPPPVPNPSPTLRPVETP VVGAPGMGSVS |
| Function | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay. Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA. May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors. In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist. (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. |
| Protein Name | Grb10-Interacting Gyf Protein 2Perq Amino Acid-Rich With Gyf Domain-Containing Protein 2Trinucleotide Repeat-Containing Gene 15 Protein |
| Alternative Antibody Names | Anti-Grb10-Interacting Gyf Protein 2 antibodyAnti-Perq Amino Acid-Rich With Gyf Domain-Containing Protein 2 antibodyAnti-Trinucleotide Repeat-Containing Gene 15 Protein antibodyAnti-GIGYF2 antibodyAnti-KIAA0642 antibodyAnti-PERQ2 antibodyAnti-TNRC15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
