| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Growth hormone-inducible transmembrane protein (31-80 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GHITM |
| Gene ID: | 27069 |
| Uniprot ID: | GHITM_HUMAN |
| Immunogen Region: | 31-80 aa |
| Specificity: | GHITM Polyclonal Antibody detects endogenous levels of GHITM protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human GHITM at the amino acid range 31-80 |
| Function | Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion. Functions also as an electroneutral mitochondrial proton/potassium exchanger. Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria. However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome. |
| Protein Name | Growth Hormone-Inducible Transmembrane Protein Dermal Papilla-Derived Protein 2 Mitochondrial Morphology And Cristae Structure 1 Mics1 Transmembrane Bax Inhibitor Motif-Containing Protein 5 |
| Cellular Localisation | Mitochondrion Inner Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Growth Hormone-Inducible Transmembrane Protein antibody Anti-Dermal Papilla-Derived Protein 2 antibody Anti-Mitochondrial Morphology And Cristae Structure 1 antibody Anti-Mics1 antibody Anti-Transmembrane Bax Inhibitor Motif-Containing Protein 5 antibody Anti-GHITM antibody Anti-DERP2 antibody Anti-MICS1 antibody Anti-TMBIM5 antibody Anti-My021 antibody Anti-UNQ244 antibody Anti-PRO281 antibody |
Information sourced from Uniprot.org