Anti-GGCX antibody (479-758) (STJ111114)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GGCX (479-758) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GGCX |
| Gene ID | 2677 |
| Uniprot ID | VKGC_HUMAN |
| Immunogen Region | 479-758 |
| Immunogen Sequence | QRIFDPRVDIVQAAWSPFQR TSWVQPLLMDLSPWRAKLQE IKSSLDNHTEVVFIADFPGL HLENFVSEDLGNTSIQLLQG EVTVELVAEQKNQTLREGEK MQLPAGEYHKVYTTSPSPSC YMYVYVNTTELALEQDLAYL QELKEKVENGSETGPLPPEL QPLLEGEVKGGPEPTPLVQT FLRRQQRLQEIERRRNTPFH ERFFRFLLRKLYVFRRSFLM TCISLRNLILGRPSLEQLA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 479-758 of human GGCX (NP_000812.2). |
Additional Info
| Function | Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP). |
| Protein Name | Vitamin K-Dependent Gamma-CarboxylaseGamma-Glutamyl CarboxylasePeptidyl-Glutamate 4-CarboxylaseVitamin K Gamma Glutamyl Carboxylase |
| Database Links | Reactome: R-HSA-159740Reactome: R-HSA-9673240 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Vitamin K-Dependent Gamma-Carboxylase antibodyAnti-Gamma-Glutamyl Carboxylase antibodyAnti-Peptidyl-Glutamate 4-Carboxylase antibodyAnti-Vitamin K Gamma Glutamyl Carboxylase antibodyAnti-GGCX antibodyAnti-GC antibody |
Information sourced from Uniprot.org