| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GGCX (479-758) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GGCX |
| Gene ID: |
2677 |
| Uniprot ID: |
VKGC_HUMAN |
| Immunogen Region: |
479-758 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 479-758 of human GGCX (NP_000812.2). |
| Immunogen Sequence: |
QRIFDPRVDIVQAAWSPFQR TSWVQPLLMDLSPWRAKLQE IKSSLDNHTEVVFIADFPGL HLENFVSEDLGNTSIQLLQG EVTVELVAEQKNQTLREGEK MQLPAGEYHKVYTTSPSPSC YMYVYVNTTELALEQDLAYL QELKEKVENGSETGPLPPEL QPLLEGEVKGGPEPTPLVQT FLRRQQRLQEIERRRNTPFH ERFFRFLLRKLYVFRRSFLM TCISLRNLILGRPSLEQLA |
| Function | Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP). |
| Protein Name | Vitamin K-Dependent Gamma-CarboxylaseGamma-Glutamyl CarboxylasePeptidyl-Glutamate 4-CarboxylaseVitamin K Gamma Glutamyl Carboxylase |
| Database Links | Reactome: R-HSA-159740Reactome: R-HSA-9673240 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Vitamin K-Dependent Gamma-Carboxylase antibodyAnti-Gamma-Glutamyl Carboxylase antibodyAnti-Peptidyl-Glutamate 4-Carboxylase antibodyAnti-Vitamin K Gamma Glutamyl Carboxylase antibodyAnti-GGCX antibodyAnti-GC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
