Anti-GGA1 antibody (STJA0009105)

SKU:
STJA0009105

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ADP-ribosylation factor-binding protein GGA1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GGA1
Gene ID: 26088
Uniprot ID: GGA1_HUMAN
Specificity: This antibody detects endogenous levels of GGA1 at Human, Mouse
Immunogen: Synthesized peptide derived from human GGA1
Post Translational Modifications Phosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal DXXLL motif to bind the VHS domain and to inhibit the recognition of cargo signals. Ubiquitinated.
Function Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane. Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network.
Protein Name Adp-Ribosylation Factor-Binding Protein Gga1
Gamma-Adaptin-Related Protein 1
Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 1
Database Links Reactome: R-HSA-8854214
Reactome: R-HSA-977225
Cellular Localisation Golgi Apparatus
Trans-Golgi Network Membrane
Peripheral Membrane Protein
Endosome Membrane
Early Endosome Membrane
Alternative Antibody Names Anti-Adp-Ribosylation Factor-Binding Protein Gga1 antibody
Anti-Gamma-Adaptin-Related Protein 1 antibody
Anti-Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 1 antibody
Anti-GGA1 antibody

Information sourced from Uniprot.org

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