| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ADP-ribosylation factor-binding protein GGA1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GGA1 |
| Gene ID: | 26088 |
| Uniprot ID: | GGA1_HUMAN |
| Specificity: | This antibody detects endogenous levels of GGA1 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human GGA1 |
| Post Translational Modifications | Phosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal DXXLL motif to bind the VHS domain and to inhibit the recognition of cargo signals. Ubiquitinated. |
| Function | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane. Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network. |
| Protein Name | Adp-Ribosylation Factor-Binding Protein Gga1 Gamma-Adaptin-Related Protein 1 Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 1 |
| Database Links | Reactome: R-HSA-8854214 Reactome: R-HSA-977225 |
| Cellular Localisation | Golgi Apparatus Trans-Golgi Network Membrane Peripheral Membrane Protein Endosome Membrane Early Endosome Membrane |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Binding Protein Gga1 antibody Anti-Gamma-Adaptin-Related Protein 1 antibody Anti-Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 1 antibody Anti-GGA1 antibody |
Information sourced from Uniprot.org