Anti-GFRAL antibody [25M22] {PE} (STJA0031528)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationPE
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal Gdnf Family Receptor Alpha-Like antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 25M22 |
| Isotype | IgG1k |
| Conjugation | PE |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | GFRAL |
| Gene ID | 389400 |
| Uniprot ID | GFRAL_HUMAN |
Additional Info
| Post Translational Modifications | Cleaved and inactivated by MMP14, inhibiting the GDF15-GFRAL aversive response. |
| Function | Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues. |
| Protein Name | Gdnf Family Receptor Alpha-Like |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinExtracellular Side |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-Like antibodyAnti-GFRAL antibodyAnti-C6orf144 antibodyAnti-UNQ9356 antibodyAnti-PRO34128 antibody |
Information sourced from Uniprot.org