Anti-GFRA4 antibody (141-190 aa) (STJ93262)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GFRA4 at the amino acid range 141-190
General Information
| Short Description | Rabbit polyclonal anti-GDNF family receptor alpha-4 (141-190 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GFRA4 |
| Gene ID | 64096 |
| Uniprot ID | GFRA4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GFRA4 at the amino acid range 141-190 |
| Immunogen Region | 141-190 aa |
| Specificity | GFR Alpha-4 Polyclonal Antibody detects endogenous levels of GFR Alpha-4 protein. |
Additional Info
| Function | Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. |
| Protein Name | Gdnf Family Receptor Alpha-4Gdnf Receptor Alpha-4Gdnfr-Alpha-4Gfr-Alpha-4Persephin Receptor |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Isoform Gfralpha4a: Cell MembraneLipid-AnchorGpi-AnchorIsoform Gfralpha4b: Cell MembraneIsoform Gfralpha4c: Secreted |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-4 antibodyAnti-Gdnf Receptor Alpha-4 antibodyAnti-Gdnfr-Alpha-4 antibodyAnti-Gfr-Alpha-4 antibodyAnti-Persephin Receptor antibodyAnti-GFRA4 antibody |
Information sourced from Uniprot.org