Anti-GFRA3 antibody (32-240) (STJ23777)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GFRA3 (32-240) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GFRA3 |
| Gene ID | 2676 |
| Uniprot ID | GFRA3_HUMAN |
| Immunogen Region | 32-240 |
| Immunogen Sequence | DPLPTESRLMNSCLQARRKC QADPTCSAAYHHLDSCTSSI STPLPSEEPSVPADCLEAAQ QLRNSSLIGCMCHRRMKNQV ACLDIYWTVHRARSLGNYEL DVSPYEDTVTSKPWKMNLSK LNMLKPDSDLCLKFAMLCTL NDKCDRLRKAYGEACSGPHC QRHVCLRQLLTFFEKAAEPH AQGLLLCPCAPNDRGCGERR RNTIAPNCA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 32-240 of human GFRA3 (NP_001487.2). |
Additional Info
| Tissue Specificity | Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system. |
| Post Translational Modifications | N-glycosylated. |
| Function | Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons. ARTN-binding leads to autophosphorylation and activation of the RET receptor. |
| Protein Name | Gdnf Family Receptor Alpha-3Gdnf Receptor Alpha-3Gdnfr-Alpha-3Gfr-Alpha-3 |
| Database Links | Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-3 antibodyAnti-Gdnf Receptor Alpha-3 antibodyAnti-Gdnfr-Alpha-3 antibodyAnti-Gfr-Alpha-3 antibodyAnti-GFRA3 antibodyAnti-UNQ339 antibodyAnti-PRO538 antibodyAnti-PRO3664 antibody |
Information sourced from Uniprot.org