Anti-GFRA2 antibody (360-464) (STJ23776)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GFRA2 (360-464) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GFRA2 |
| Gene ID | 2675 |
| Uniprot ID | GFRA2_HUMAN |
| Immunogen Region | 360-464 |
| Immunogen Sequence | DVNVSPKGPSFQATQAPRVE KTPSLPDDLSDSTSLGTSVI TTCTSVQEQGLKANNSKELS MCFTELTTNIIPGSNKVIKP NSGPSRARPSAALTVLSVLM LKLAL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 360-464 of human GFRA2 (NP_001486.4). |
Additional Info
| Tissue Specificity | Isoform 1: found in both brain and placenta. |
| Function | Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3. |
| Protein Name | Gdnf Family Receptor Alpha-2Gdnf Receptor Alpha-2Gdnfr-Alpha-2Gfr-Alpha-2Gdnf Receptor BetaGdnfr-BetaNeurturin Receptor AlphaNrtnr-AlphaNtnr-AlphaRet Ligand 2Tgf-Beta-Related Neurotrophic Factor Receptor 2 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-2 antibodyAnti-Gdnf Receptor Alpha-2 antibodyAnti-Gdnfr-Alpha-2 antibodyAnti-Gfr-Alpha-2 antibodyAnti-Gdnf Receptor Beta antibodyAnti-Gdnfr-Beta antibodyAnti-Neurturin Receptor Alpha antibodyAnti-Nrtnr-Alpha antibodyAnti-Ntnr-Alpha antibodyAnti-Ret Ligand 2 antibodyAnti-Tgf-Beta-Related Neurotrophic Factor Receptor 2 antibodyAnti-GFRA2 antibodyAnti-GDNFRB antibodyAnti-RETL2 antibodyAnti-TRNR2 antibody |
Information sourced from Uniprot.org