Anti-GET3 antibody (112-162) (STJA0006636)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ASNA AA range: 112-162
General Information
| Short Description | Rabbit polyclonal anti-ATPase GET3 (112-162) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GET3 |
| Gene ID | 439 |
| Uniprot ID | GET3_HUMAN |
| Immunogen | Synthesized peptide derived from human ASNA AA range: 112-162 |
| Immunogen Region | 112-162 |
| Specificity | This antibody detects endogenous levels of human ASNA |
Additional Info
| Function | ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. |
| Protein Name | Atpase Get3Arsenical Pump-Driving AtpaseArsenite-Stimulated AtpaseGuided Entry Of Tail-Anchored Proteins Factor 3 - AtpaseTransmembrane Domain Recognition Complex 40 Kda Atpase SubunitHarsa-IHasna-I |
| Database Links | Reactome: R-HSA-9609523 |
| Cellular Localisation | CytoplasmEndoplasmic ReticulumNucleusNucleolus |
| Alternative Antibody Names | Anti-Atpase Get3 antibodyAnti-Arsenical Pump-Driving Atpase antibodyAnti-Arsenite-Stimulated Atpase antibodyAnti-Guided Entry Of Tail-Anchored Proteins Factor 3 - Atpase antibodyAnti-Transmembrane Domain Recognition Complex 40 Kda Atpase Subunit antibodyAnti-Harsa-I antibodyAnti-Hasna-I antibodyAnti-GET3 antibodyAnti-ARSA antibodyAnti-ASNA1 antibodyAnti-TRC40 antibody |
Information sourced from Uniprot.org