Anti-Geminin antibody (1-209 aa) [2H7] (STJA0041494)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human Geminin (1-209 aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-Geminin (1-209 aa) for use in ELISA and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2H7 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GMNN |
| Gene ID | 51053 |
| Uniprot ID | GEMI_HUMAN |
| Accession Number | NP_056979 |
| Immunogen | Recombinant human Geminin (1-209 aa) purified from E. coli |
| Immunogen Region | 1-209 aa |
Additional Info
| Post Translational Modifications | Phosphorylated during mitosis. Phosphorylation at Ser-184 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity. |
| Function | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control. |
| Protein Name | Geminin |
| Database Links | Reactome: R-HSA-68867Reactome: R-HSA-68962Reactome: R-HSA-69052 |
| Cellular Localisation | CytoplasmNucleusMainly Cytoplasmic But Can Be Relocalized To The Nucleus |
| Alternative Antibody Names | Anti-Geminin antibodyAnti-GMNN antibody |
Information sourced from Uniprot.org