Anti-GEMIN7 antibody (1-131) (STJ117383)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GEMIN7 (1-131) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GEMIN7 |
| Gene ID | 79760 |
| Uniprot ID | GEMI7_HUMAN |
| Immunogen Region | 1-131 |
| Immunogen Sequence | MQTPVNIPVPVLRLPRGPDG FSRGFAPDGRRAPLRPEVPE IQECPIAQESLESQEQRARA ALRERYLRSLLAMVGHQVSF TLHEGVRVAAHFGATDLDVA NFYVSQLQTPIGVQAEALLR CSDIISYTFKP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-131 of human GEMIN7 (NP_078983.1). |
Additional Info
| Function | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. |
| Protein Name | Gem-Associated Protein 7Gemin-7Sip3 |
| Database Links | Reactome: R-HSA-191859Reactome: R-HSA-9754678 |
| Cellular Localisation | NucleusNucleoplasmGemCytoplasmFound Both In The Nucleoplasm And In Nuclear Bodies Called Gems (Gemini Of Cajal Bodies) That Are Often In Proximity To Cajal (Coiled) BodiesAlso Found In The Cytoplasm |
| Alternative Antibody Names | Anti-Gem-Associated Protein 7 antibodyAnti-Gemin-7 antibodyAnti-Sip3 antibodyAnti-GEMIN7 antibody |
Information sourced from Uniprot.org