Anti-GDNF Receptor alpha 1/GFRA1 antibody (361-460 aa) [SRM5391] (STJ11107301)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal GDNF Receptor alpha 1/GFRA1 (361-460 aa) antibody for use in IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5391 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:100-1:400ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GFRA1 |
| Gene ID | 2674 |
| Uniprot ID | GFRA1_HUMAN |
| Immunogen Region | 361-460 aa |
| Immunogen Sequence | QTTTATTTTALRVKNKPLGP AGSENEIPTHVLPPCANLQA QKLKSNVSGNTHLCISNGNY EKEGLGASSHITTKSMAAPP SCGLSPLLVLVVTALSTLLS |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 361-460 of human GDNF Receptor alpha 1/GFRA1 (NP_005255.1). |
Additional Info
| Function | Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor. |
| Protein Name | Gdnf Family Receptor Alpha-1Gdnf Receptor Alpha-1Gdnfr-Alpha-1Gfr-Alpha-1Ret Ligand 1Tgf-Beta-Related Neurotrophic Factor Receptor 1 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659Reactome: R-HSA-9830674 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorGolgi ApparatusTrans-Golgi NetworkEndosomeMultivesicular BodyLocalizes Mainly To The Plasma MembraneIn The Presence Of Sorl1Shifts To Vesicular StructuresIncluding Trans-Golgi NetworkEndosomes And Multivesicular Bodies |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-1 antibodyAnti-Gdnf Receptor Alpha-1 antibodyAnti-Gdnfr-Alpha-1 antibodyAnti-Gfr-Alpha-1 antibodyAnti-Ret Ligand 1 antibodyAnti-Tgf-Beta-Related Neurotrophic Factor Receptor 1 antibodyAnti-GFRA1 antibodyAnti-GDNFRA antibodyAnti-RETL1 antibodyAnti-TRNR1 antibody |
Information sourced from Uniprot.org