| Host: | Chicken |
| Applications: | IHC-F/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Chicken polyclonal anti-GDNF family receptor alpha-4 for use in IHC-F and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgY |
| Formulation: | Concentrated ammonium sulphate in PBS pH 7.4 containing no preservatives. |
| Purification: | Affinity-purified |
| Dilution Range: | WB 1:5000-1:10000ICC 1:1000-1:3000 |
| Storage Instruction: | ready to dilute once thawedStore at-80°C upon receipt. Divide antibody into aliquots upon receipt. Avoid multiple freeze-thaw cycles as product degradation may result. |
| Gene Symbol: | GFRA4 |
| Gene ID: | 64096 |
| Uniprot ID: | GFRA4_HUMAN |
| Specificity: | Human GFRa-4. This antibody does not cross-react with hGFRa-1, hGFRa-2, hGFRa-3. |
| Immunogen: | Recombinant His-tagged human GFRa-4 protein produced using CHO-based cell line. For production of hGFRa-4, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein was purified by Ni-affin |
| Immunogen Sequence: | Human |
| Tissue Specificity | Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands. |
| Function | Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. |
| Protein Name | Gdnf Family Receptor Alpha-4Gdnf Receptor Alpha-4Gdnfr-Alpha-4Gfr-Alpha-4Persephin Receptor |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Isoform Gfralpha4a: Cell MembraneLipid-AnchorGpi-AnchorIsoform Gfralpha4b: Cell MembraneIsoform Gfralpha4c: Secreted |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-4 antibodyAnti-Gdnf Receptor Alpha-4 antibodyAnti-Gdnfr-Alpha-4 antibodyAnti-Gfr-Alpha-4 antibodyAnti-Persephin Receptor antibodyAnti-GFRA4 antibody |
Information sourced from Uniprot.org
