Anti-GDNF family receptor alpha-1 antibody (STJA0040695)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenRecombinant His-tagged human GFR alpha-1 protein produced using CHO-based cell line. For production of hGFR alpha-1, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein was purified b
General Information
| Short Description | Chicken polyclonal anti-GDNF family receptor alpha-1 for use in ICC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/WB |
| Host | Chicken |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Purification | Affinity-purified |
| Dilution Range | WB 1:5000-1:10000ICC 1:500-1:2000 |
| Formulation | Concentrated ammonium sulphate in PBS pH 7.4 containing no preservatives. |
| Storage Instruction | Store antibody stock solution at +4Β°C upon receipt. DO NOT FREEZE. This product is an (NH4) 2SO4 precipitate. To use, mix well by pipetting or vortexing gently prior use, then withdraw the desired amount of antibody stock solution and dilute into you |
Target Information
| Gene Symbol | GFRA1 |
| Gene ID | 2674 |
| Uniprot ID | GFRA1_HUMAN |
| Immunogen | Recombinant His-tagged human GFR alpha-1 protein produced using CHO-based cell line. For production of hGFR alpha-1, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein was purified b |
| Immunogen Sequence | Human |
| Specificity | Human GFR alpha-1. No cross reaction with hGFR alpha-2, hGFR alpha-3, hGFR alpha-4. |
Additional Info
| Function | Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor. |
| Protein Name | Gdnf Family Receptor Alpha-1Gdnf Receptor Alpha-1Gdnfr-Alpha-1Gfr-Alpha-1Ret Ligand 1Tgf-Beta-Related Neurotrophic Factor Receptor 1 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659Reactome: R-HSA-9830674 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorGolgi ApparatusTrans-Golgi NetworkEndosomeMultivesicular BodyLocalizes Mainly To The Plasma MembraneIn The Presence Of Sorl1Shifts To Vesicular StructuresIncluding Trans-Golgi NetworkEndosomes And Multivesicular Bodies |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-1 antibodyAnti-Gdnf Receptor Alpha-1 antibodyAnti-Gdnfr-Alpha-1 antibodyAnti-Gfr-Alpha-1 antibodyAnti-Ret Ligand 1 antibodyAnti-Tgf-Beta-Related Neurotrophic Factor Receptor 1 antibodyAnti-GFRA1 antibodyAnti-GDNFRA antibodyAnti-RETL1 antibodyAnti-TRNR1 antibody |
Information sourced from Uniprot.org