Anti-GDF5 antibody (361-410 aa) (STJ96667)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human GDF5 at the amino acid range 361-410
General Information
| Short Description | Rabbit polyclonal anti-Growth/differentiation factor 5 (361-410 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GDF5 |
| Gene ID | 8200 |
| Uniprot ID | GDF5_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human GDF5 at the amino acid range 361-410 |
| Immunogen Region | 361-410 aa |
| Specificity | GDF-5 Polyclonal Antibody detects endogenous levels of GDF-5 protein. |
Additional Info
| Function | Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. |
| Protein Name | Growth/Differentiation Factor 5Gdf-5Bone Morphogenetic Protein 14Bmp-14Cartilage-Derived Morphogenetic Protein 1Cdmp-1Lipopolysaccharide-Associated Protein 4Lap-4Lps-Associated Protein 4Radotermin |
| Database Links | Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedCell Membrane |
| Alternative Antibody Names | Anti-Growth/Differentiation Factor 5 antibodyAnti-Gdf-5 antibodyAnti-Bone Morphogenetic Protein 14 antibodyAnti-Bmp-14 antibodyAnti-Cartilage-Derived Morphogenetic Protein 1 antibodyAnti-Cdmp-1 antibodyAnti-Lipopolysaccharide-Associated Protein 4 antibodyAnti-Lap-4 antibodyAnti-Lps-Associated Protein 4 antibodyAnti-Radotermin antibodyAnti-GDF5 antibodyAnti-BMP14 antibodyAnti-CDMP1 antibody |
Information sourced from Uniprot.org