Anti-GDF11 antibody (60-100) {FITC} (STJ500272)

SKU:
STJ500272-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GDF11 (60-100) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.66 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GDF11
Gene ID: 10220
Uniprot ID: GDF11_HUMAN
Immunogen Region: 60-100
Immunogen: Synthetic peptide taken within amino acid region 60-100 on human BMP11/GDF11 protein.
Tissue Specificity In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme.
Post Translational Modifications Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases. This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase.
Function Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.
Protein Name Growth/Differentiation Factor 11
Gdf-11
Bone Morphogenetic Protein 11
Bmp-11
Cellular Localisation Secreted
Alternative Antibody Names Anti-Growth/Differentiation Factor 11 antibody
Anti-Gdf-11 antibody
Anti-Bone Morphogenetic Protein 11 antibody
Anti-Bmp-11 antibody
Anti-GDF11 antibody
Anti-BMP11 antibody

Information sourced from Uniprot.org

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