Anti-GCNA antibody (444-494 aa) (STJ194621)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ACRC at the amino acid range 444-494
General Information
| Short Description | Rabbit polyclonal anti-Germ cell nuclear acidic protein (444-494 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GCNA |
| Gene ID | 93953 |
| Uniprot ID | GCNA_HUMAN |
| Immunogen | Synthesized peptide derived from the human ACRC at the amino acid range 444-494 |
| Immunogen Region | 444-494 aa |
| Specificity | This antibody detects endogenous levels of ACRC at Human |
Additional Info
| Function | May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage. Can resolve the topoisomerase II (TOP2A) DPCs. |
| Protein Name | Germ Cell Nuclear Acidic ProteinAcidic Repeat-Containing ProteinGerm Cell Nuclear Acidic PeptidaseGerm Cell Nuclear Antigen |
| Database Links | |
| Cellular Localisation | NucleusPml BodyChromosomeCo-Localizes With Sumo2 At Pml Bodies In All Interphase CellsLocalizes On Condensed Chromosomes In Spermatocytes In G2 And M During Meiotic Prophase |
| Alternative Antibody Names | Anti-Germ Cell Nuclear Acidic Protein antibodyAnti-Acidic Repeat-Containing Protein antibodyAnti-Germ Cell Nuclear Acidic Peptidase antibodyAnti-Germ Cell Nuclear Antigen antibodyAnti-GCNA antibodyAnti-ACRC antibody |
Information sourced from Uniprot.org