Anti-GCLC antibody (538-637) [S9MR] (STJ11102089)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal GCLC (538-637) antibody for use in WB, IHC-P and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S9MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GCLC |
| Gene ID | 2729 |
| Uniprot ID | GSH1_HUMAN |
| Immunogen Region | 538-637 |
| Immunogen Sequence | LNSYLENMEVDVDTRCSILN YLKLIKKRASGELMTVARWM REFIANHPDYKQDSVITDEM NYSLILKCNQIANELCECPE LLGSAFRKVKYSGSKTDSSN |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 538-637 of human GCLC (P48506). |
Additional Info
| Function | Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis. |
| Protein Name | Glutamate--Cysteine Ligase Catalytic SubunitGcs Heavy ChainGamma-EcsGamma-Glutamylcysteine Synthetase |
| Database Links | Reactome: R-HSA-174403Reactome: R-HSA-5578999Reactome: R-HSA-9818027 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Glutamate--Cysteine Ligase Catalytic Subunit antibodyAnti-Gcs Heavy Chain antibodyAnti-Gamma-Ecs antibodyAnti-Gamma-Glutamylcysteine Synthetase antibodyAnti-GCLC antibodyAnti-GLCL antibodyAnti-GLCLC antibody |
Information sourced from Uniprot.org