• Western blot analysis of lysates from DU145 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-GCH1 antibody (STJ190842)

SKU:
STJ190842

€57.50 - €282.50
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GTP cyclohydrolase 1 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GCH1
Gene ID: 2643
Uniprot ID: GCH1_HUMAN
Specificity: GCH1 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Phosphorylated by casein kinase II at Ser-81 in HAECs during oscillatory shear stress.phosphorylation at Ser-81 results in increased enzyme activity.
Function Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.
Protein Name Gtp Cyclohydrolase 1
Gtp Cyclohydrolase I
Gtp-Ch-I
Database Links Reactome: R-HSA-1474151
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Gtp Cyclohydrolase 1 antibody
Anti-Gtp Cyclohydrolase I antibody
Anti-Gtp-Ch-I antibody
Anti-GCH1 antibody
Anti-DYT5 antibody
Anti-GCH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance