Anti-GCGR antibody [mAb1] {PE} (STJA0031378)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationPE
IsotypeIgG1k
General Information
| Short Description | Rat monoclonal Glucagon Receptor antibody for use in ELISA and FC in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC |
| Host | Rat |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | mAb1 |
| Isotype | IgG1k |
| Conjugation | PE |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | Gcgr |
| Gene ID | 14527 |
| Uniprot ID | GLR_MOUSE |
Additional Info
| Post Translational Modifications | Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding. |
| Function | G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. |
| Protein Name | Glucagon ReceptorGl-R |
| Database Links | Reactome: R-MMU-163359Reactome: -MMU-416476Reactome: -MMU-418555Reactome: -MMU-420092 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinIs Rapidly Internalized After Ligand-Binding |
| Alternative Antibody Names | Anti-Glucagon Receptor antibodyAnti-Gl-R antibodyAnti-Gcgr antibody |
Information sourced from Uniprot.org