| Tissue Specificity | Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine. |
| Post Translational Modifications | Allele GC*1S is O-glycosylated at Thr-436. The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated. The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated. |
| Function | Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. |
| Protein Name | Vitamin D-Binding ProteinDbpVdbGc Protein-Derived Macrophage Activating FactorGc-MafGcmafGc-GlobulinGroup-Specific ComponentGcVitamin D-Binding Protein-Macrophage Activating FactorDbp-Maf |
| Database Links | Reactome: R-HSA-196791 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Vitamin D-Binding Protein antibodyAnti-Dbp antibodyAnti-Vdb antibodyAnti-Gc Protein-Derived Macrophage Activating Factor antibodyAnti-Gc-Maf antibodyAnti-Gcmaf antibodyAnti-Gc-Globulin antibodyAnti-Group-Specific Component antibodyAnti-Gc antibodyAnti-Vitamin D-Binding Protein-Macrophage Activating Factor antibodyAnti-Dbp-Maf antibodyAnti-GC antibody |
Information sourced from Uniprot.org
