| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GBP2 (410-520) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GBP2 |
| Gene ID: |
2634 |
| Uniprot ID: |
GBP2_HUMAN |
| Immunogen Region: |
410-520 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 410-520 of human GBP2 (NP_004111.2). |
| Immunogen Sequence: |
QDIFGPLEEDVKQGTFSKPG GYRLFTQKLQELKNKYYQVP RKGIQAKEVLKKYLESKEDV ADALLQTDQSLSEKEKAIEV ERIKAESAEAAKKMLEEIQK KNEEMMEQKEK |
| Post Translational Modifications | (Microbial infection) Ubiquitinated by S.flexneri IpaH9.8, leading to its degradation by the proteasome, thereby preventing its ability to promote host defense against bacterial infection. Isoprenylation is required for proper subcellular location. |
| Function | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. Confers protection to the protozoan pathogen Toxoplasma gondii. Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins. |
| Protein Name | Guanylate-Binding Protein 2Gtp-Binding Protein 2Gbp-2Hugbp-2Guanine Nucleotide-Binding Protein 2Interferon-Induced Guanylate-Binding Protein 2 |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-909733 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneLipid-AnchorGolgi Apparatus MembraneCytoplasmPerinuclear RegionGbp2-Gbp5 Dimers Localize To The Golgi Apparatus |
| Alternative Antibody Names | Anti-Guanylate-Binding Protein 2 antibodyAnti-Gtp-Binding Protein 2 antibodyAnti-Gbp-2 antibodyAnti-Hugbp-2 antibodyAnti-Guanine Nucleotide-Binding Protein 2 antibodyAnti-Interferon-Induced Guanylate-Binding Protein 2 antibodyAnti-GBP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
