Anti-GBA2 antibody (708-927) (STJ114700)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GBA2 (708-927) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GBA2 |
| Gene ID | 57704 |
| Uniprot ID | GBA2_HUMAN |
| Immunogen Region | 708-927 |
| Immunogen Sequence | AQDIQDKFSSILSRGQEAYE RLLWNGRYYNYDSSSRPQSR SVMSDQCAGQWFLKACGLGE GDTEVFPTQHVVRALQTIFE LNVQAFAGGAMGAVNGMQPH GVPDKSSVQSDEVWVGVVYG LAATMIQEGLTWEGFQTAEG CYRTVWERLGLAFQTPEAYC QQRVFRSLAYMRPLSIWAMQ LALQQQQHKKASWPKVKQGT GLRTGPMFGPKEAMANLSPE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 708-927 of human GBA2 (NP_065995.1). |
Additional Info
| Tissue Specificity | Widely expressed. Mainly expressed in brain, heart, skeletal muscle, kidney and placenta and expressed at lower levels in liver, spleen, small intestine and lung. Detectable in colon, thymus and peripheral blood leukocytes. |
| Function | Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine). GlcCers are membrane glycosphingolipids that have a wide intracellular distribution. They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties. Involved in the transglucosylation of cholesterol, transfers glucose from GlcCer to cholesterol, thereby modifying its water solubility and biological properties. Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-3-beta-D-glucoside to ceramide (such as N-acylsphing-4-enine) (Probable). May play a role in the metabolism of bile acids. Able to hydrolyze bile acid 3-O-glucosides as well as to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the galactosyl transfer between GalCers and cholesterol in vitro with lower activity compared with their activity against GlcCers. |
| Protein Name | Non-Lysosomal GlucosylceramidaseNlgaseBeta-Glucocerebrosidase 2Beta-Glucosidase 2Bile Acid Beta-Glucosidase Gba2Bile Acid Glucosyl Transferase Gba2Cholesterol Glucosyltransferase Gba2Cholesteryl-Beta-Glucosidase Gba2Glucosylceramidase 2Non-Lysosomal Cholesterol GlycosyltransferaseNon-Lysosomal GalactosylceramidaseNon-Lysosomal Glycosylceramidase |
| Database Links | Reactome: R-HSA-9840310 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideGolgi Apparatus MembraneLocalization To The Plasma Membrane And Alternative Topologies Have Also Been Reported |
| Alternative Antibody Names | Anti-Non-Lysosomal Glucosylceramidase antibodyAnti-Nlgase antibodyAnti-Beta-Glucocerebrosidase 2 antibodyAnti-Beta-Glucosidase 2 antibodyAnti-Bile Acid Beta-Glucosidase Gba2 antibodyAnti-Bile Acid Glucosyl Transferase Gba2 antibodyAnti-Cholesterol Glucosyltransferase Gba2 antibodyAnti-Cholesteryl-Beta-Glucosidase Gba2 antibodyAnti-Glucosylceramidase 2 antibodyAnti-Non-Lysosomal Cholesterol Glycosyltransferase antibodyAnti-Non-Lysosomal Galactosylceramidase antibodyAnti-Non-Lysosomal Glycosylceramidase antibodyAnti-GBA2 antibodyAnti-KIAA1605 antibodyAnti-SPG46 antibodyAnti-AD035 antibody |
Information sourced from Uniprot.org