Anti-GATM antibody (223-273 aa) (STJ194901)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human GATM at the amino acid range 223-273
General Information
| Short Description | Rabbit polyclonal anti-Glycine amidinotransferase, mitochondrial (223-273 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GATM |
| Gene ID | 2628 |
| Uniprot ID | GATM_HUMAN |
| Immunogen | Synthesized peptide derived from the human GATM at the amino acid range 223-273 |
| Immunogen Region | 223-273 aa |
| Specificity | This antibody detects endogenous levels of GATM at Human/Mouse/Rat |
Additional Info
| Function | Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (Probable). |
| Protein Name | Glycine Amidinotransferase - MitochondrialL-Arginine -Glycine AmidinotransferaseTransamidinase |
| Database Links | Reactome: R-HSA-71288 |
| Cellular Localisation | Isoform 1: Mitochondrion Inner MembranePeripheral Membrane ProteinIntermembrane SideProbably Attached To The Outer Side Of The Inner MembraneIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Glycine Amidinotransferase - Mitochondrial antibodyAnti-L-Arginine -Glycine Amidinotransferase antibodyAnti-Transamidinase antibodyAnti-GATM antibodyAnti-AGAT antibody |
Information sourced from Uniprot.org