| Short Description : | Rabbit polyclonal GATM (38-423) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GATM |
| Gene ID: | 2628 |
| Uniprot ID: | GATM_HUMAN |
| Immunogen Region: | 38-423 |
| Immunogen Sequence: | STQAATASSRNSCAADDKAT EPLPKDCPVSSYNEWDPLEE VIVGRAENACVPPFTIEVKA NTYEKYWPFYQKQGGHYFPK DHLKKAVAEIEEMCNILKTE GVTVRRPDPIDWSLKYKTPD FESTGLYSAMPRDILIVVGN EIIEAPMAWRSRFFEYRAYR SIIKDYFHRGAKWTTAPKPT MADELYNQDYPIHSVEDRHK LAAQGKFVTTEFEPCFDAAD FIRAGRDIFAQRSQVTNYL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 38-423 of human GATM (NP_001473.1?). |
| Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues. |
| Function | Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (Probable). |
| Protein Name | Glycine Amidinotransferase - MitochondrialL-Arginine -Glycine AmidinotransferaseTransamidinase |
| Database Links | Reactome: R-HSA-71288 |
| Cellular Localisation | Isoform 1: Mitochondrion Inner MembranePeripheral Membrane ProteinIntermembrane SideProbably Attached To The Outer Side Of The Inner MembraneIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Glycine Amidinotransferase - Mitochondrial antibodyAnti-L-Arginine -Glycine Amidinotransferase antibodyAnti-Transamidinase antibodyAnti-GATM antibodyAnti-AGAT antibody |
Information sourced from Uniprot.org
