Anti-GATA4 antibody [6H10] (STJ98101)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2b
ImmunogenPurified recombinant fragment of human GATA-4 expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Transcription factor GATA-4 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 6H10 |
| Isotype | IgG2b |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GATA4 |
| Gene ID | 2626 |
| Uniprot ID | GATA4_HUMAN |
| Immunogen | Purified recombinant fragment of human GATA-4 expressed in E. Coli. |
| Specificity | GATA-4 Monoclonal Antibody detects endogenous levels of GATA-4 protein. |
Additional Info
| Function | Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase. |
| Protein Name | Transcription Factor Gata-4Gata-Binding Factor 4 |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-400511Reactome: R-HSA-5578768Reactome: R-HSA-9690406Reactome: R-HSA-9733709Reactome: R-HSA-9758920Reactome: R-HSA-9823730Reactome: R-HSA-983231Reactome: R-HSA-9925561 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Gata-4 antibodyAnti-Gata-Binding Factor 4 antibodyAnti-GATA4 antibody |
Information sourced from Uniprot.org