Anti-Gastrin antibody (76-85 aa) (STJA0040919)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic human Gastrin peptide (76-85 aa) conjugated to BSA.
General Information
| Short Description | Rabbit polyclonal anti-Gastrin (76-85 aa) for use in ICC, IHC-F and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/IHC-F/IHC-P |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity-purified |
| Dilution Range | IHC 5-15 µg/mLICC 5-15 µg/mL |
| Formulation | Lyophilized with BSA. |
| Storage Instruction | Spin vial briefly before opening. Reconstitute in 0.05 mL of sterile-filtered PBS (pH 7.4). Centrifuge to remove any insoluble material. At least 12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at |
Target Information
| Gene Symbol | GAST |
| Gene ID | 2520 |
| Uniprot ID | GAST_HUMAN |
| Immunogen | Synthetic human Gastrin peptide (76-85 aa) conjugated to BSA. |
| Immunogen Region | 76-85 aa |
| Immunogen Sequence | Human |
| Specificity | Human Gastrin, Cross reactivity is expected with mouse, rat, other species not yet tested. |
Additional Info
| Post Translational Modifications | Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific. |
| Function | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. |
| Protein Name | Gastrin Cleaved Into - Gastrin-71Gastrin Component I - Gastrin-52G52 - Big GastrinGastrin Component IiGastrin-34G34 - GastrinGastrin Component IiiGastrin-17G17 - Gastrin-14G14 - Gastrin-6G6 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-881907 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Gastrin Cleaved Into - Gastrin-71 antibodyAnti-Gastrin Component I - Gastrin-52 antibodyAnti-G52 - Big Gastrin antibodyAnti-Gastrin Component Ii antibodyAnti-Gastrin-34 antibodyAnti-G34 - Gastrin antibodyAnti-Gastrin Component Iii antibodyAnti-Gastrin-17 antibodyAnti-G17 - Gastrin-14 antibodyAnti-G14 - Gastrin-6 antibodyAnti-G6 antibodyAnti-GAST antibodyAnti-GAS antibody |
Information sourced from Uniprot.org