| Function | Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner. |
| Protein Name | Dynein Regulatory Complex Subunit 4Growth Arrest-Specific Protein 11Gas-11Growth Arrest-Specific Protein 8Gas-8 |
| Database Links | Reactome: R-HSA-5635838 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionCiliumFlagellumCilium AxonemeCilium Basal BodyGolgi ApparatusFlagellum AxonemeAssociates With MicrotubulesLocalized To The Cytoplasm Of Round SpermatidsThe Tails Of Elongating SpermatidsAnd Mature Spermatid Tail Bundles Protruding Into The LumenAnd In The Flagellum Of Epididymal Spermatozoa |
| Alternative Antibody Names | Anti-Dynein Regulatory Complex Subunit 4 antibodyAnti-Growth Arrest-Specific Protein 11 antibodyAnti-Gas-11 antibodyAnti-Growth Arrest-Specific Protein 8 antibodyAnti-Gas-8 antibodyAnti-GAS8 antibodyAnti-DRC4 antibodyAnti-GAS11 antibody |
Information sourced from Uniprot.org
