• Immunohistochemical analysis of paraffin-embedded human spleen tissue. 1, primary Antibody was diluted at 1:200 (4°C overnight). 2, Sodium citrate pH 6.0 was used for antigen retrieval (>98°C, 20min). 3, Secondary antibody was diluted at 1:200

Anti-GAS8 antibody (Internal) (STJ93219)

SKU:
STJ93219

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dynein regulatory complex subunit 4 (Internal) is suitable for use in Immunohistochemistry, Immunofluorescence, Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GAS8
Gene ID: 2622
Uniprot ID: DRC4_HUMAN
Immunogen Region: Internal
Specificity: Gas8 Polyclonal Antibody detects endogenous levels of Gas8 protein.
Immunogen: Synthesized peptide derived from the Internal region of human Gas8.
Function Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner.
Protein Name Dynein Regulatory Complex Subunit 4
Growth Arrest-Specific Protein 11
Gas-11
Growth Arrest-Specific Protein 8
Gas-8
Database Links Reactome: R-HSA-5635838
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Cilium
Flagellum
Cilium Axoneme
Cilium Basal Body
Golgi Apparatus
Flagellum Axoneme
Associates With Microtubules
Localized To The Cytoplasm Of Round Spermatids
The Tails Of Elongating Spermatids
And Mature Spermatid Tail Bundles Protruding Into The Lumen
And In The Flagellum Of Epididymal Spermatozoa
Alternative Antibody Names Anti-Dynein Regulatory Complex Subunit 4 antibody
Anti-Growth Arrest-Specific Protein 11 antibody
Anti-Gas-11 antibody
Anti-Growth Arrest-Specific Protein 8 antibody
Anti-Gas-8 antibody
Anti-GAS8 antibody
Anti-DRC4 antibody
Anti-GAS11 antibody

Information sourced from Uniprot.org

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