Anti-GAS6 antibody (600-700) [PTR1202] (STJA0038938)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenSynthesized peptide derived from human GAS6. AA range:600-700
General Information
| Short Description | Mouse monoclonal anti-Growth Arrest-Specific Protein 6 (600-700) for use in WB, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PTR1202 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | Protein G |
| Dilution Range | WB 1:500-2000IF 1:100-500ELISA 1:1000-5000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GAS6 |
| Gene ID | 2621 |
| Uniprot ID | GAS6_HUMAN |
| Immunogen | Synthesized peptide derived from human GAS6. AA range:600-700 |
| Immunogen Region | 600-700 |
| Specificity | This antibody detects endogenous levels of GAS6. |
Additional Info
| Post Translational Modifications | Isoform 2: Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL. Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. |
| Function | Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry. |
| Protein Name | Growth Arrest-Specific Protein 6Gas-6Axl Receptor Tyrosine Kinase Ligand |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-159740Reactome: R-HSA-159763Reactome: R-HSA-159782Reactome: R-HSA-202733Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Growth Arrest-Specific Protein 6 antibodyAnti-Gas-6 antibodyAnti-Axl Receptor Tyrosine Kinase Ligand antibodyAnti-GAS6 antibodyAnti-AXLLG antibody |
Information sourced from Uniprot.org