• Western blot analysis of the lysates from HT-29 cells using GAS6 antibody.
  • Western blot analysis of lysates from 293 cells, using GAS6 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of 293 cells using Gas6 Polyclonal Antibody diluted at 1：500
  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GAS6 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Gas6 Polyclonal Antibody diluted at 1：500

Anti-GAS6 antibody (291-340 aa) (STJ93218)

SKU:
STJ93218

$62.10 - $305.10
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Growth arrest-specific protein 6 (291-340 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GAS6
Gene ID: 2621
Uniprot ID: GAS6_HUMAN
Immunogen Region: 291-340 aa
Specificity: Gas6 Polyclonal Antibody detects endogenous levels of Gas6 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human GAS6 at the amino acid range 291-340
Post Translational Modifications Isoform 2: Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL. Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
Function Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry.
Protein Name Growth Arrest-Specific Protein 6
Gas-6
Axl Receptor Tyrosine Kinase Ligand
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-159740
Reactome: R-HSA-159763
Reactome: R-HSA-159782
Reactome: R-HSA-202733
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation Secreted
Alternative Antibody Names Anti-Growth Arrest-Specific Protein 6 antibody
Anti-Gas-6 antibody
Anti-Axl Receptor Tyrosine Kinase Ligand antibody
Anti-GAS6 antibody
Anti-AXLLG antibody

Information sourced from Uniprot.org

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