Anti-GARS1 antibody (N-Term) (STJA0010325)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human N-ternal SYG
General Information
| Short Description | Rabbit polyclonal anti-Glycine--tRNA ligase (N-Term) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GARS1 |
| Gene ID | 2617 |
| Uniprot ID | GARS_HUMAN |
| Immunogen | Synthesized peptide derived from human N-ternal SYG |
| Immunogen Region | N-Term |
| Specificity | This antibody detects endogenous levels of SYG at Human, Mouse, Rat |
Additional Info
| Function | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. |
| Protein Name | Glycine--Trna LigaseDiadenosine Tetraphosphate SynthetaseAp4a SynthetaseGlycyl-Trna SynthetaseGlyrsGlycyl-Trna Synthetase 1 |
| Database Links | Reactome: R-HSA-379716Reactome: R-HSA-379726 |
| Cellular Localisation | CytoplasmCell ProjectionAxonSecretedExtracellular ExosomeIn Transfected Cos7 CellsNot Detected In MitochondriaNor In Golgi ApparatusSecreted By Motor NeuronPossibly Through The Exosome PathwayIsoform 1: MitochondrionIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Glycine--Trna Ligase antibodyAnti-Diadenosine Tetraphosphate Synthetase antibodyAnti-Ap4a Synthetase antibodyAnti-Glycyl-Trna Synthetase antibodyAnti-Glyrs antibodyAnti-Glycyl-Trna Synthetase 1 antibodyAnti-GARS1 antibodyAnti-GARS antibody |
Information sourced from Uniprot.org