Anti-Galectin 1 antibody [R01-7A5] (STJA0034342)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Galectin 1
General Information
| Short Description | Rabbit monoclonal anti-Galectin 1 for use in WB, IHC-P and IP in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-7A5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | LGALS1 |
| Gene ID | 3956 |
| Uniprot ID | LEG1_HUMAN |
| Immunogen | A synthetic peptide of human Galectin 1 |
Additional Info
| Tissue Specificity | Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. |
| Function | Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69. |
| Protein Name | Galectin-1Gal-114 Kda Laminin-Binding ProteinHlbp1414 Kda LectinBeta-Galactoside-Binding Lectin L-14-IGalaptinHblHplLactose-Binding Lectin 1Lectin Galactoside-Binding Soluble 1Putative Mapk-Activating Protein Pm12S-Lac Lectin 1 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixCytoplasmCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Galectin-1 antibodyAnti-Gal-1 antibodyAnti-14 Kda Laminin-Binding Protein antibodyAnti-Hlbp14 antibodyAnti-14 Kda Lectin antibodyAnti-Beta-Galactoside-Binding Lectin L-14-I antibodyAnti-Galaptin antibodyAnti-Hbl antibodyAnti-Hpl antibodyAnti-Lactose-Binding Lectin 1 antibodyAnti-Lectin Galactoside-Binding Soluble 1 antibodyAnti-Putative Mapk-Activating Protein Pm12 antibodyAnti-S-Lac Lectin 1 antibodyAnti-LGALS1 antibody |
Information sourced from Uniprot.org