| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GALE (129-348) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GALE |
| Gene ID: |
2582 |
| Uniprot ID: |
GALE_HUMAN |
| Immunogen Region: |
129-348 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 129-348 of human GALE (NP_001121093.1). |
| Immunogen Sequence: |
FSSSATVYGNPQYLPLDEAH PTGGCTNPYGKSKFFIEEMI RDLCQADKTWNAVLLRYFNP TGAHASGCIGEDPQGIPNNL MPYVSQVAIGRREALNVFGN DYDTEDGTGVRDYIHVVDLA KGHIAALRKLKEQCGCRIYN LGTGTGYSVLQMVQAMEKAS GKKIPYKVVARREGDVAACY ANPSLAQEELGWTAALGLDR MCEDLWRWQKQNPSGFGTQA |
| Function | Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. |
| Protein Name | Udp-Glucose 4-EpimeraseGalactowaldenaseUdp-N-Acetylgalactosamine 4-EpimeraseUdp-Galnac 4-EpimeraseUdp-N-Acetylglucosamine 4-EpimeraseUdp-Glcnac 4-EpimeraseUdp-Galactose 4-Epimerase |
| Database Links | Reactome: R-HSA-5609977Reactome: R-HSA-70370 |
| Alternative Antibody Names | Anti-Udp-Glucose 4-Epimerase antibodyAnti-Galactowaldenase antibodyAnti-Udp-N-Acetylgalactosamine 4-Epimerase antibodyAnti-Udp-Galnac 4-Epimerase antibodyAnti-Udp-N-Acetylglucosamine 4-Epimerase antibodyAnti-Udp-Glcnac 4-Epimerase antibodyAnti-Udp-Galactose 4-Epimerase antibodyAnti-GALE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
