| Function | Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69. |
| Protein Name | Galectin-1Gal-114 Kda Laminin-Binding ProteinHlbp1414 Kda LectinBeta-Galactoside-Binding Lectin L-14-IGalaptinHblHplLactose-Binding Lectin 1Lectin Galactoside-Binding Soluble 1Putative Mapk-Activating Protein Pm12S-Lac Lectin 1 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixCytoplasmCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Nanobody Names | Anti-Galectin-1 nanobodyAnti-Gal-1 nanobodyAnti-14 Kda Laminin-Binding Protein nanobodyAnti-Hlbp14 nanobodyAnti-14 Kda Lectin nanobodyAnti-Beta-Galactoside-Binding Lectin L-14-I nanobodyAnti-Galaptin nanobodyAnti-Hbl nanobodyAnti-Hpl nanobodyAnti-Lactose-Binding Lectin 1 nanobodyAnti-Lectin Galactoside-Binding Soluble 1 nanobodyAnti-Putative Mapk-Activating Protein Pm12 nanobodyAnti-S-Lac Lectin 1 nanobodyAnti-LGALS1 nanobody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and Galectin 1/Galectin 1/LGALS1 knockout (KO) 293T cells, using [KO Validated] Galectin 1/LGALS1 Rabbit polyclonal antibody (STJ11100013) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89086/357546/STJ11100013_1__69675.1713121665.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Galectin 1/Galectin 1/LGALS1 knockout (KO) 293T cells, using [KO Validated] Galectin 1/LGALS1 Rabbit polyclonal antibody (STJ11100013) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.")