Anti-Gal-1/LGALS1 nanobody [SAA2310] (STJN000687)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-His
General Information
| Short Description | Alpaca monoclonal nanobody anti-Gal-1/LGALS1 is suitable for use in ELISA and Western Blot research applications. |
| Applications | ELISA/WB |
| Host | Alpaca |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA2310 |
| Isotype | VHH-His |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Purified by Nickel column. |
| Dilution Range | ELISA: 1:2000-1:20000; WB: 1:500-1:2000 |
| Formulation | 0.01M PBS pH 7.4 |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact with the lab for this information. |
Target Information
| Gene Symbol | LGALS1 |
| Gene ID | 3956 |
| Uniprot ID | LEG1_HUMAN |
Additional Info
| Function | Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69. |
| Protein Name | Galectin-1Gal-114 Kda Laminin-Binding ProteinHlbp1414 Kda LectinBeta-Galactoside-Binding Lectin L-14-IGalaptinHblHplLactose-Binding Lectin 1Lectin Galactoside-Binding Soluble 1Putative Mapk-Activating Protein Pm12S-Lac Lectin 1 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixCytoplasmCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Nanobody Names | Anti-Galectin-1 nanobodyAnti-Gal-1 nanobodyAnti-14 Kda Laminin-Binding Protein nanobodyAnti-Hlbp14 nanobodyAnti-14 Kda Lectin nanobodyAnti-Beta-Galactoside-Binding Lectin L-14-I nanobodyAnti-Galaptin nanobodyAnti-Hbl nanobodyAnti-Hpl nanobodyAnti-Lactose-Binding Lectin 1 nanobodyAnti-Lectin Galactoside-Binding Soluble 1 nanobodyAnti-Putative Mapk-Activating Protein Pm12 nanobodyAnti-S-Lac Lectin 1 nanobodyAnti-LGALS1 nanobody |
Information sourced from Uniprot.org