![Anti-GAK nanobody [SAA1190] (STJN000038)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200651/412833/STJN000038-SDS-PAGE-1__64732.1749232384.jpg?c=1 "Anti-GAK nanobody [SAA1190] (STJN000038)")
![Anti-GAK nanobody [SAA1190] (STJN000038)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200651/412833/STJN000038-SDS-PAGE-1__64732.1749232384.jpg?c=1 "Anti-GAK nanobody [SAA1190] (STJN000038)")
Anti-GAK nanobody [SAA1190] (STJN000038)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Cyclin-G-Associated Kinase is suitable for use in ELISA and SPR research applications. |
| Applications | ELISA/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1190 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | GAK |
| Gene ID | 2580 |
| Uniprot ID | GAK_HUMAN |
Additional Info
| Function | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly. |
| Protein Name | Cyclin-G-Associated KinaseDnaj Homolog Subfamily C Member 26 |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmPerinuclear RegionGolgi ApparatusTrans-Golgi NetworkCell JunctionFocal AdhesionCytoplasmic VesicleClathrin-Coated VesicleLocalizes To The Perinuclear Area And To The Trans-Golgi NetworkAlso Seen On The Plasma MembraneProbably At Focal AdhesionsRecruitment To Clathrin-Coated Vesicles Depends On Temporal Variations In Phosphoinositide Composition Of Clathrin-Coated Vesicles |
| Alternative Nanobody Names | Anti-Cyclin-G-Associated Kinase nanobodyAnti-Dnaj Homolog Subfamily C Member 26 nanobodyAnti-GAK nanobodyAnti-DNAJC26 nanobody |
Information sourced from Uniprot.org