| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Large ribosomal subunit protein mL64 (91-140 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GADD45GIP1 |
| Gene ID: |
90480 |
| Uniprot ID: |
G45IP_HUMAN |
| Immunogen Region: |
91-140 aa |
| Specificity: |
CRIF1 Polyclonal Antibody detects endogenous levels of CRIF1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human GADD45GIP1 at the amino acid range 91-140 |
| Function | Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. |
| Protein Name | Large Ribosomal Subunit Protein Ml6439s Ribosomal Protein L59 - MitochondrialMrp-L59Ckii Beta-Associating ProteinCr6-Interacting Factor 1Crif1Growth Arrest And Dna Damage-Inducible Proteins-Interacting Protein 1Papillomavirus L2-Interacting Nuclear Protein 1PlinpPlinp-1P53-Responsive Gene 6 Protein |
| Database Links | Reactome: R-HSA-5368286Reactome: R-HSA-5389840Reactome: R-HSA-5419276 |
| Cellular Localisation | MitochondrionNucleusUsing N-Terminally Tagged ConstructsHas Been Found In The NucleusC-Terminally Tagged Constructs Are Targeted Exclusively To MitochondriaThis Discrepancy May Be Explained By Masking Of A Potential N-Terminal Mitochondrial Targeting Signal By The Tag |
| Alternative Antibody Names | Anti-Large Ribosomal Subunit Protein Ml64 antibodyAnti-39s Ribosomal Protein L59 - Mitochondrial antibodyAnti-Mrp-L59 antibodyAnti-Ckii Beta-Associating Protein antibodyAnti-Cr6-Interacting Factor 1 antibodyAnti-Crif1 antibodyAnti-Growth Arrest And Dna Damage-Inducible Proteins-Interacting Protein 1 antibodyAnti-Papillomavirus L2-Interacting Nuclear Protein 1 antibodyAnti-Plinp antibodyAnti-Plinp-1 antibodyAnti-P53-Responsive Gene 6 Protein antibodyAnti-GADD45GIP1 antibodyAnti-MRPL59 antibodyAnti-PLINP1 antibodyAnti-PRG6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
